When I'm home running or on a day hike, I prefer to pierce the skin as soon as a blister forms and drain all fluid from a blister to reduce the pain and further irritation/inflammation. In this case, I know I can get antibacterials and a thorough wash to ward off infection as well as stronger measures if the blister does become infected.
Of course hiking with a tube of neosporin and some tape, moleskin, whatever you prefer is ideal, but I'm wondering what people feel is best for blister care when you are going to keep walking for a few days or more when you discover a nice blister has already formed.
Are you a "pop it now" person, or a strict "let it pop itself" person?
Does not having anti-bacterial cream change your stance?