I want to travel by canoe from [Ohiopyle State Park](https://www.dcnr.pa.gov/StateParks/FindAPark/OhiopyleStatePark/Pages/default.aspx) to Cumberland, MD on the [Youghiogheny](https://en.wikipedia.org/wiki/Youghiogheny_River) and [Potomac](http://en.wikipedia.org/wiki/Potomac_River) Rivers

What are the navigation considerations?  Also I will have a bike and trailer for the canoe, will be interested in bike trails paralleling or intersecting the river.

* Locks and Dams
* Camping/accommodations
* Launches 
* River side services (away from large cities) 

Hypothetically the trip would be completed, with only muscle power, rowing or pedaling.  In either a single trip or by pedaling upstream and rowing down stream, in one or more outings. 

Related (West) https://outdoors.stackexchange.com/questions/7239